Switch needing to avoid PI for DOAC

Mutations: RT_74V, 115F, 184V, 215Y, 101H, 181C
Comorbidities: None
Comedications: None
Treatment history: None
Current regimen: DRV/c (Darunavir-cobicistat/Prezcobix) , DTG (Dolutegravir/Tivicay) , MVC (Maraviroc/Selzentry)
Adherence: Administration preference: Penalize IV/IM/SC dosing
CD4: > 200
Viral load: Suppressed (<50) for less than 6 months or Low Level Viremia (<200)
HLA-B5701: Negative
Tropism: R5 virus
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Submitted by clippin1 on

Currently receiving MVC + DRV/c + DTG and virologically suppressed. Newly diagnosed DVT/PE likely requiring lifelong anticoagulation with desire to use DOAC rather than coumadin (thus avoiding PI).

Score Code Regimen Weighted Score Active Drugs Total Pills Frequency (x/day)
2 DTG+DRV/c 1.75 2 2 1
2 DTG+DRV/c/TAF/FTC 1.9 2.67 2 1
2 DRV/c+DTG/TDF/3TC 2 2.67 2 1
2 DRV/c+BIC/TAF/FTC 2 2.67 2 1
2 DTG+DRV/c+DOR 2.06 3 3 1
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