55 year old recent COVID and on vent. 2010: Genotype L10V, M46I, A71T, L89V, L90M, M184V. (resistance to protease inhibitors (except darunavir) and emtricitabine/3TC (M184V)).2014 start on darunavir/ritonavir, dolutegravir2015: VL undetectable. However, daily hives. Switched to raltegravir, etravirine, emtricitabine, TDF 2015: undetectable viral load2018: 2280 copies/mL , CD4 1382018: 469 copies/mL, CD4 2452018: CD4 257 with VL undetectable2019: new high viral load of 100KGenotype not done2020: severe illness with COVID,: K65R Y181C. INSTI genotype without resistance mutations. CD4 count 96 (but total lymphocyte count is 250-700 during that time)
| Regimen | Weighted Score | Active Drugs | Total Pills | Frequency (x/day) |
|---|---|---|---|---|
| DTG+3TC/AZT | 5.95 | 2 | 4 | 2 |
| DTG+AZT+FTC | 6.15 | 2 | 5 | 2 |
| DTG+IBA | 6.4 | 2 | 2 | 2 |
| DTG+IBA+DOR | 6.75 | 2.67 | 3 | 2 |
| DTG+AZT+TDF | 6.75 | 2.33 | 5 | 2 |