Results

Mutations: RT_74V, 115F, 184V, 215Y, 101H, 181C
Comorbidities: None
Comedications: None
Treatment history: None
Current regimen: DRV/c (Darunavir-cobicistat/Prezcobix) , DTG (Dolutegravir/Tivicay) , MVC (Maraviroc/Selzentry)
Adherence: Administration preference: Penalize IV/IM/SC dosing
CD4: > 200
Viral load: Suppressed (<50) for less than 6 months or Low Level Viremia (<200)
HLA-B5701: Negative
Tropism: R5 virus
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Score Code Regimen Weighted Score Active Drugs Total Pills Frequency (x/day)
2 DTG+DRV/c 1.75 2 2 1
2 DTG+DRV/c/TAF/FTC 1.9 2.67 2 1
2 DRV/c+DTG/TDF/3TC 2 2.67 2 1
2 DRV/c+BIC/TAF/FTC 2 2.67 2 1
2 DTG+DRV/c+DOR 2.06 3 3 1
2 DTG+RPV+DRV/c/TAF/FTC 2.06 3 3 1
2 DRV/c+RPV+BIC/TAF/FTC 2.15 3 3 1
2 DTG+MVC+DRV/c [Current regimen] 2.15 3 4 2
2 DRV/c+RPV+DTG/TDF/3TC 2.16 3 3 1
2 DTG+DRV/c+RPV/TDF/FTC 2.16 3 3 1
2 DTG+DRV/c+TDF/FTC 2.2 2.67 3 1
3 BIC/TAF/FTC 2.63 1.67 1 1
3 DTG/TDF/3TC 2.63 1.67 1 1
3 DTG+TAF/FTC 2.63 1.67 2 1
3 DTG+TDF/FTC 2.63 1.67 2 1
3 DTG+MVC+DOR 2.91 3 4 2
3 RAL+DRV/c/TAF/FTC 3.1 2.67 3 1
3 DRV/c/TAF/FTC 3.13 1.67 1 1
3 DTG+MVC 3.2 2 3 2
3 DRV/c+TDF/FTC 3.23 1.67 2 1
3 RAL+DRV/c+DOR 3.25 3 4 1
3 DTG+DOR/TDF/3TC 3.26 2.67 2 1
3 RAL+RPV+DRV/c/TAF/FTC 3.35 3 4 1
3 DTG+DOR 3.41 2 2 1
3 DTG+DOR+TAF/FTC 3.46 2.67 3 1
3 DTG+DOR+TDF/FTC 3.46 2.67 3 1
3 RAL+DRV/c+TDF/FTC 3.5 2.67 4 1
3 RAL+DRV/c+RPV/TDF/FTC 3.55 3 4 1
3 DOR+BIC/TAF/FTC 3.75 2.67 2 1
3 MVC+DTG/TDF/3TC 3.85 2.67 3 2
4 DTG+MVC+TAF/FTC 4.05 2.67 4 2
4 DTG+MVC+TDF/FTC 4.05 2.67 4 2
4 RAL+DRV/c 4.2 2 3 1
4 MVC+BIC/TAF/FTC 4.35 2.67 3 2
4 DTG+DRV/c+3TC/AZT 4.4 2.33 4 2
4 DRV/c+DTG/RPV 4.86 2.33 2 1
4 DTG+RPV/TAF/FTC 4.91 2 2 1
4 DTG+RPV/TDF/FTC 4.91 2 2 1
4 RPV+DTG/TDF/3TC 4.91 2 2 1
4 DTG+DOR+DRV/c/TAF/FTC 5.06 3.67 3 1
4 DOR+DRV/c/TAF/FTC 5.1 2.67 2 1
4 DRV/c+DOR+BIC/TAF/FTC 5.15 3.67 3 1
4 DTG+DRV/c+DOR/TDF/3TC 5.16 3.67 3 1
4 DRV/c+DOR/TDF/3TC 5.2 2.67 2 1
4 RAL+MVC+DRV/c 5.35 3 5 2
4 DTG+DRV/c+DOR+TDF/FTC 5.36 3.67 4 1
4 RPV+BIC/TAF/FTC 5.4 2 2 1
4 DRV/c+DOR+TDF/FTC 5.4 2.67 3 1
4 DTG+FTR+DRV/c 5.4 3 4 2
4 DTG+IBA+DRV/c 5.5 3 2 1
4 DTG+DRV/c+AZT+FTC 5.6 2.33 5 2
4 MVC+DTG/RPV 5.71 2.33 3 2
4 DRV/c+AZT+FTC+DTG/RPV 5.71 2.67 5 2
4 DTG+DRV/c+RPV+3TC/AZT 5.71 2.67 5 2
4 DRV/c+DOR 5.85 2 2 1
4 DTG+FTR+DOR 5.91 3 4 2
5 DTG+LEN+DRV/c 6 3 2 1
5 DOR+EVG/c/TAF/FTC 6.05 2.67 2 1
5 DOR+EVG/c/TDF/FTC 6.05 2.67 2 1
5 DTG+MVC+DRV/c/TAF/FTC 6.15 3.67 4 2
5 DTG+FTR 6.2 2 3 2
5 MVC+DRV/c+DTG/TDF/3TC 6.25 3.67 4 2
5 MVC+DRV/c+BIC/TAF/FTC 6.25 3.67 4 2
5 RAL+DOR+DRV/c/TAF/FTC 6.25 3.67 4 1
5 DTG+IBA+DOR 6.26 3 2 1
5 DTG+3TC/AZT 6.28 1.33 3 2
5 DTG+FTR+MVC+DRV/c 6.3 4 6 2
5 RAL+DRV/c+DOR/TDF/3TC 6.45 3.67 4 1
5 DTG+MVC+DRV/c+TDF/FTC 6.45 3.67 5 2
5 DTG+AZT+FTC 6.48 1.33 4 2
5 DTG+EFV/TDF/FTC 6.5 2 3 2
5 DTG+LEN+DOR 6.51 3 2 1
5 RAL+DRV/c+RPV 6.6 2.33 4 1
5 RAL+DRV/c+3TC/AZT 6.6 2.33 5 2
5 RAL+DRV/c+DOR+TDF/FTC 6.65 3.67 5 1
5 RAL+IBA+DRV/c 6.7 3 3 1
5 DTG+IBA 6.75 2 1 1
5 DTG+LEN 6.75 2 1 1
5 RPV+DRV/c/TAF/FTC 6.75 2 2 1
5 DTG+MVC+DRV/c+DOR 6.76 4 5 2
5 RAL+DRV/c+AZT+FTC 6.8 2.33 6 2
5 DRV/c+RPV/TDF/FTC 6.85 2 2 1
5 DTG+MVC+3TC/AZT 6.85 2.33 5 2
5 FTR+DTG/TDF/3TC 6.9 2.67 3 2
5 DTG+IBA+MVC+DRV/c 6.9 4 4 2
5 DTG+DOR+3TC/AZT 6.91 2.33 4 2
5 DTG+MVC+AZT+FTC 7.05 2.33 6 2
5 RAL+DOR/TDF/3TC 7.05 2.67 3 1
5 DTG+FTR+TAF/FTC 7.1 2.67 4 2
5 DTG+FTR+TDF/FTC 7.1 2.67 4 2
5 RAL+DOR+TAF/FTC 7.15 2.67 4 1
5 MVC+DRV/c 7.19 2 3 2
5 RAL+LEN+DRV/c 7.2 3 3 1
5 EFV+DTG/TDF/3TC 7.25 2 3 2
5 RAL+DOR+TDF/FTC 7.25 2.67 4 1
5 RAL+DRV/c+RPV+3TC/AZT 7.25 2.67 6 2
5 IBA+DTG/TDF/3TC 7.4 2.67 1 1
5 DTG+IBA+TAF/FTC 7.4 2.67 2 1
5 DTG+IBA+TDF/FTC 7.4 2.67 2 1
5 FTR+BIC/TAF/FTC 7.4 2.67 3 2
5 DTG+EFV+TAF/FTC 7.45 2 4 2
5 RAL+DRV/c+RPV+AZT+FTC 7.45 2.67 7 2
5 DTG+DRV/c+DOR+3TC/AZT 7.46 3.33 5 2
5 DRV/c+3TC/AZT 7.53 1.33 3 2
5 MVC+DRV/c/TAF/FTC 7.6 2.67 3 2
5 RAL+FTR+DRV/c 7.6 3 5 2
5 DTG+FTR+MVC+DOR 7.61 4 6 2
5 LEN+DTG/TDF/3TC 7.65 2.67 1 1
5 DTG+LEN+TAF/FTC 7.65 2.67 2 1
5 DTG+LEN+TDF/FTC 7.65 2.67 2 1
5 DTG+DRV/c+DOR+AZT+FTC 7.66 3.33 6 2
5 MVC+DRV/c+DOR 7.7 3 4 2
5 DRV/c+AZT+FTC 7.73 1.33 4 2
5 RAL+MVC+DRV/c/TAF/FTC 7.85 3.67 5 2
5 IBA+BIC/TAF/FTC 7.9 2.67 1 1
5 MVC+DRV/c+TDF/FTC 7.9 2.67 4 2
5 RAL+FTR+MVC+DRV/c 8 4 7 2
5 DTG+MVC+DRV/c+3TC/AZT 8.05 3.33 6 2
5 DTG+DOR+AZT+FTC 8.11 2.33 5 2
5 LEN+BIC/TAF/FTC 8.15 2.67 1 1
5 DTG+MVC+DRV/c+AZT+FTC 8.25 3.33 7 2
5 RAL+MVC+DRV/c+TDF/FTC 8.25 3.67 6 2
5 MVC+DRV/c+DTG/RPV 8.36 3.33 4 2
5 RAL+MVC+DRV/c+DOR 8.45 4 6 2
5 DTG+IBA+MVC+DOR 8.46 4 4 2
5 RAL+IBA+MVC+DRV/c 8.6 4 5 2
5 MVC+EVG/c/TAF/FTC 8.65 2.67 3 2
5 RAL+DRV/c+DOR+3TC/AZT 8.65 3.33 6 2
5 DRV/c+DOR+3TC/AZT 8.75 2.33 4 2
5 FTR+DTG/RPV 8.81 2.33 3 2
5 AZT+FTC+DTG/RPV 8.84 1.67 4 2
5 DTG+RPV+3TC/AZT 8.84 1.67 4 2
5 RAL+DOR 8.85 2 3 1
5 RAL+DRV/c+DOR+AZT+FTC 8.85 3.33 7 2
5 DTG+FTR+DRV/c/TAF/FTC 8.95 3.67 4 2
5 DTG+IBA+DRV/c/TAF/FTC 9 3.67 2 1
5 DTG+LEN+IBA+DRV/c 9 4 2 1
5 FTR+DRV/c+DTG/TDF/3TC 9.05 3.67 4 2
5 FTR+DRV/c+BIC/TAF/FTC 9.05 3.67 4 2
5 IBA+DRV/c+DTG/TDF/3TC 9.1 3.67 2 1
5 IBA+DRV/c+BIC/TAF/FTC 9.1 3.67 2 1
5 RPV+EVG/c/TAF/FTC 9.2 2 2 1
5 DTG+FTR+DRV/c+TDF/FTC 9.25 3.67 5 2
5 IBA+DTG/RPV 9.26 2.33 1 1
5 RAL+MVC 9.3 2 4 2
5 DTG+IBA+DRV/c+TDF/FTC 9.3 3.67 3 1
5 FTR+MVC+DTG/RPV 9.31 3.33 5 2
5 RAL+MVC+DOR 9.35 3 5 2
5 DTG+MVC+EFV 9.45 2.33 5 2
5 LEN+DTG/RPV 9.51 2.33 1 1
5 DTG+FTR+DRV/c+DOR 9.51 4 5 2
5 EVG/c/TAF/FTC 9.55 1.67 1 1
5 RAL+EFV/TDF/FTC 9.6 2 3 1
5 DTG+IBA+DRV/c+DOR 9.61 4 3 1
5 EVG/c/TDF/FTC 9.65 1.67 1 1
5 DTG+FTR+IBA+DRV/c 9.65 4 4 2
5 RAL+RPV/TAF/FTC 9.7 2 3 1
5 DTG+LEN+3TC/AZT 9.7 2.33 3 2
5 DTG+IBA+3TC/AZT 9.7 2.33 3 2
5 RAL+MVC+DRV/c+3TC/AZT 9.75 3.33 7 2
5 DTG+LEN+DRV/c/TAF/FTC 9.75 3.67 2 1
5 RAL+RPV/TDF/FTC 9.8 2 3 1
5 DTG+FTR+3TC/AZT 9.85 2.33 5 2
5 LEN+DRV/c+DTG/TDF/3TC 9.85 3.67 2 1
5 LEN+DRV/c+BIC/TAF/FTC 9.85 3.67 2 1
5 DTG+LEN+AZT+FTC 9.9 2.33 4 2
5 DTG+IBA+AZT+FTC 9.9 2.33 4 2
5 FTR+DRV/c 9.94 2 3 2
5 DRV/c+DOR+AZT+FTC 9.95 2.33 5 2
5 RAL+MVC+DRV/c+AZT+FTC 9.95 3.33 8 2
5 DTG+FTR+AZT+FTC 10.05 2.33 6 2
5 DTG+LEN+DRV/c+TDF/FTC 10.05 3.67 3 1
5 IBA+MVC+DTG/RPV 10.06 3.33 3 2
5 RAL+TAF/FTC 10.15 1.67 3 1
5 IBA+DRV/c 10.15 2 1 1
5 RAL+FTR+DRV/c/TAF/FTC 10.15 3.67 5 2
5 RAL+IBA+DRV/c/TAF/FTC 10.2 3.67 3 1
5 LEN+RAL+IBA+DRV/c 10.2 4 3 1
5 RAL+TDF/FTC 10.25 1.67 3 1
5 DTG+LEN+DRV/c+DOR 10.36 4 3 1
5 DTG+LEN+FTR+DRV/c 10.4 4 4 2
5 RAL+EFV+TAF/FTC 10.45 2 4 1
5 FTR+DRV/c+DOR 10.45 3 4 2
5 IBA+DRV/c+DOR 10.55 3 2 1
5 RAL+FTR+DRV/c+TDF/FTC 10.55 3.67 6 2
5 MVC+DRV/c+3TC/AZT 10.6 2.33 5 2
5 RAL+MVC+DRV/c+RPV 10.6 3.33 6 2
5 RAL+IBA+DRV/c+TDF/FTC 10.6 3.67 4 1
5 DTG+LEN+MVC+DRV/c 10.65 4 4 2
5 RAL+FTR+DRV/c+DOR 10.7 4 6 2
5 LEN+DRV/c 10.74 2 1 1
5 RAL+MVC+TAF/FTC 10.75 2.67 5 2
5 MVC+DRV/c+AZT+FTC 10.8 2.33 6 2
5 DTG+FTR+DRV/c+3TC/AZT 10.8 3.33 6 2
5 RAL+IBA+DRV/c+DOR 10.8 4 4 1
5 DTG+LEN+IBA+DOR 10.81 4 2 1
5 RAL+MVC+TDF/FTC 10.85 2.67 5 2
5 RAL+FTR+IBA+DRV/c 10.85 4 5 2
5 FTR+DRV/c/TAF/FTC 10.9 2.67 3 2
5 DRV/c+RPV+3TC/AZT 10.93 1.67 4 2
5 MVC+DRV/c+RPV 10.95 2.33 4 2
5 LEN+RAL+DRV/c/TAF/FTC 10.95 3.67 3 1
5 DTG+FTR+DRV/c+AZT+FTC 11 3.33 7 2
5 FTR+DRV/c+TDF/FTC 11.2 2.67 4 2
5 IBA+DRV/c+DTG/RPV 11.21 3.33 2 1
5 FTR+DRV/c+DTG/RPV 11.21 3.33 4 2
5 DTG+IBA+EFV 11.3 2.33 3 2
5 LEN+DRV/c+DOR 11.3 3 2 1
5 DOR/TDF/3TC 11.35 1.67 1 1
5 DOR+TAF/FTC 11.35 1.67 2 1
5 LEN+RAL+DRV/c+TDF/FTC 11.35 3.67 4 1
5 IBA+DRV/c/TAF/FTC 11.4 2.67 1 1
5 DTG+IBA+DRV/c+3TC/AZT 11.4 3.33 4 2
5 DTG+FTR+EFV 11.45 2.33 5 2
5 DTG+FTR+IBA+DOR 11.46 4 4 2
5 IBA+DRV/c+TDF/FTC 11.5 2.67 2 1
5 LEN+RAL+DRV/c+DOR 11.55 4 4 1
5 DTG+IBA+DRV/c+AZT+FTC 11.6 3.33 5 2
5 LEN+RAL+FTR+DRV/c 11.6 4 5 2
5 RAL+IBA+DOR 11.65 3 3 1
5 FTR+EVG/c/TAF/FTC 11.7 2.67 3 2
5 FTR+EVG/c/TDF/FTC 11.7 2.67 3 2
5 DTG+EFV+3TC/AZT 11.78 1.67 5 2
5 RAL+FTR 11.89 2 4 2
5 LEN+DRV/c/TAF/FTC 11.9 2.67 1 1
5 LEN+RAL+DOR 11.9 3 3 1
5 DTG+LEN+DRV/c+3TC/AZT 11.9 3.33 4 2
5 DTG+FTR+MVC+EFV 11.95 3.33 7 2
5 LEN+DRV/c+DTG/RPV 11.96 3.33 2 1
5 DTG+LEN+MVC+DOR 11.96 4 4 2
5 DTG+LEN+FTR+DOR 11.96 4 4 2
5 DTG+EFV+AZT+FTC 11.98 1.67 6 2
5 LEN+DRV/c+TDF/FTC 12 2.67 2 1
5 RAL+FTR+DRV/c+3TC/AZT 12 3.33 7 2
5 DTG+LEN+DRV/c+AZT+FTC 12.1 3.33 5 2
5 DRV/c+RPV+AZT+FTC 12.13 1.67 5 2
5 RAL+IBA 12.15 2 2 1
5 RAL+FTR+DRV/c+AZT+FTC 12.2 3.33 8 2
5 RAL+LEN 12.24 2 2 1
5 RAL+FTR+DOR 12.3 3 5 2
5 LEN+RAL+MVC+DRV/c 12.35 4 5 2
5 IBA+EVG/c/TAF/FTC 12.45 2.67 1 1
5 IBA+EVG/c/TDF/FTC 12.45 2.67 1 1
5 CAB/RPV 12.55 1.33 0 0.03
5 RAL+ETR+TAF/FTC 12.6 2 5 2
5 RAL+IBA+DRV/c+3TC/AZT 12.6 3.33 5 2
5 FTR+MVC+DRV/c+DOR 12.6 4 6 2
5 LEN+IBA+DTG/RPV 12.61 3.33 1 1
5 RAL+ETR+TDF/FTC 12.7 2 5 2
5 LEN+EVG/c/TAF/FTC 12.7 2.67 1 1
5 LEN+EVG/c/TDF/FTC 12.7 2.67 1 1
5 DOR+TDF/FTC 12.75 1.67 2 1
5 DTG+IBA+MVC+EFV 12.8 3.33 5 2
5 RAL+IBA+DRV/c+AZT+FTC 12.8 3.33 6 2
5 RAL+IBA+DRV/c+RPV 12.95 3.33 4 1
5 RAL+FTR+DRV/c+RPV 12.95 3.33 6 2
5 LEN+RAL+DRV/c+3TC/AZT 13.1 3.33 5 2
5 FTR+IBA+DTG/RPV 13.16 3.33 3 2
5 RAL+MVC+RPV 13.2 2.33 5 2
5 IBA+MVC+DRV/c+DOR 13.2 4 4 2
5 LEN+RAL+DRV/c+AZT+FTC 13.3 3.33 6 2
5 RAL+LEN+TAF/FTC 13.35 2.67 3 1
5 RAL+IBA+TAF/FTC 13.35 2.67 3 1
5 RAL+LEN+TDF/FTC 13.45 2.67 3 1
5 RAL+IBA+TDF/FTC 13.45 2.67 3 1
5 RAL+FTR+MVC+DOR 13.45 4 7 2
5 DTG/RPV 13.46 1.33 1 1
5 LEN+MVC+DTG/RPV 13.56 3.33 3 2
5 LEN+FTR+DTG/RPV 13.66 3.33 3 2
5 IBA+DRV/c+3TC/AZT 13.7 2.33 3 2
5 LEN+RAL+DRV/c+RPV 13.7 3.33 4 1
5 IBA+DRV/c+RPV 13.8 2.33 2 1
5 FTR+DRV/c+RPV 13.8 2.33 4 2
5 RAL+FTR+TAF/FTC 13.8 2.67 5 2
5 DRV/c+RPV 13.85 1.33 2 1
5 FTR+DRV/c+3TC/AZT 13.85 2.33 5 2
5 IBA+DRV/c+AZT+FTC 13.9 2.33 4 2
5 RAL+FTR+TDF/FTC 13.9 2.67 5 2
5 EFV/TDF/FTC 13.95 1 1 1
5 RPV/TAF/FTC 13.95 1 1 1
5 LEN+DRV/c+3TC/AZT 13.95 2.33 3 2
5 FTR+DRV/c+AZT+FTC 14.05 2.33 6 2
5 LEN+DRV/c+AZT+FTC 14.15 2.33 4 2
5 RAL+MVC+EFV 14.2 2.33 5 2
5 RAL+IBA+MVC+DOR 14.3 4 5 2
5 RAL+DOR+3TC/AZT 14.35 2.33 5 2
5 RPV/TDF/FTC 14.45 1 1 1
5 LEN+DRV/c+RPV 14.55 2.33 2 1
5 RAL+DOR+AZT+FTC 14.55 2.33 6 2
5 EFV+TAF/FTC 14.7 1 2 1
5 FTR+MVC+DRV/c+RPV 14.75 3.33 6 2
5 DTG+FTR+IBA+EFV 14.8 3.33 5 2
5 RAL+MVC+ETR 14.85 2.33 6 2
5 RAL+3TC/AZT 14.9 1.33 4 2
5 IBA+MVC+DRV/c+RPV 15.25 3.33 4 2
5 RAL+MVC+3TC/AZT 15.3 2.33 6 2
5 RAL+MVC+AZT+FTC 15.5 2.33 7 2
5 LEN+IBA+DRV/c+DOR 15.55 4 2 1
5 RAL+RPV 15.6 1.33 3 1
5 DTG+EFV 15.7 1.33 3 2
5 RAL+EFV 15.7 1.33 3 1
5 RAL+FTR+MVC+RPV 15.7 3.33 7 2
5 RAL+IBA+EFV 15.75 2.33 3 1
5 RAL+IBA+RPV 15.75 2.33 3 1
5 FTR+IBA+DRV/c+DOR 15.95 4 4 2
5 LEN+RAL+RPV 16 2.33 3 1
5 ETR+TAF/FTC 16.05 1 3 2
5 ETR+TDF/FTC 16.05 1 3 2
5 RAL+AZT+FTC 16.1 1.33 5 2
5 LEN+RAL+IBA+DOR 16.15 4 3 1
5 RAL+FTR+EFV 16.4 2.33 5 2
5 RAL+IBA+MVC+RPV 16.45 3.33 5 2
5 RAL+FTR+RPV 16.5 2.33 5 2
5 RAL+FTR+MVC+EFV 16.6 3.33 7 2
5 DOR+3TC/AZT 16.7 1.33 3 2
5 RAL+FTR+IBA+DOR 16.8 4 5 2
5 RAL+ETR 16.85 1.33 4 2
5 DOR+AZT+FTC 16.9 1.33 4 2
5 RAL+IBA+ETR 16.9 2.33 4 2
5 LEN+FTR+DRV/c+DOR 16.95 4 4 2
5 RAL+FTR+ETR 17.15 2.33 6 2
5 LEN+MVC+DRV/c+DOR 17.2 4 4 2
5 LEN+RAL+FTR+DOR 17.3 4 5 2
5 RAL+FTR+MVC+ETR 17.35 3.33 8 2
5 RAL+IBA+MVC+EFV 17.45 3.33 5 2
5 LEN+IBA+DRV/c+RPV 17.6 3.33 2 1
5 LEN+RAL+MVC+DOR 17.8 4 5 2
5 RPV+3TC/AZT 17.95 0.67 3 2
5 ETR+3TC/AZT 18.1 0.67 4 2
5 FTR+IBA+DRV/c+RPV 18.1 3.33 4 2
5 RAL+IBA+MVC+ETR 18.1 3.33 6 2
5 RPV+AZT+FTC 18.15 0.67 4 2
5 RAL+LEN+3TC/AZT 18.15 2.33 4 2
5 RAL+FTR+3TC/AZT 18.3 2.33 6 2
5 LEN+RAL+IBA+RPV 18.3 3.33 3 1
5 RAL+IBA+3TC/AZT 18.4 2.33 4 2
5 EFV+3TC/AZT 18.45 0.67 3 2
5 RAL+FTR+AZT+FTC 18.5 2.33 7 2
5 EFV+AZT+FTC 18.65 0.67 4 2
5 LEN+RAL+ETR 18.8 2.33 4 2
5 RAL+FTR+IBA+EFV 18.95 3.33 5 2
5 RAL+FTR+IBA+RPV 19.05 3.33 5 2
5 LEN+FTR+DRV/c+RPV 19.1 3.33 4 2
5 LEN+MVC+DRV/c+RPV 19.25 3.33 4 2
5 ETR+AZT+FTC 19.3 0.67 5 2
5 RAL+RPV+3TC/AZT 19.3 1.67 5 2
5 RAL+LEN+AZT+FTC 19.35 2.33 5 2
5 RAL+RPV+AZT+FTC 19.5 1.67 6 2
5 LEN+RAL+FTR+RPV 19.55 3.33 5 2
5 RAL+IBA+AZT+FTC 19.6 2.33 5 2
5 RAL+EFV+3TC/AZT 19.7 1.67 5 2
5 RAL+FTR+IBA+ETR 19.7 3.33 6 2
5 RAL+EFV+AZT+FTC 19.9 1.67 6 2
5 LEN+RAL+MVC+RPV 19.95 3.33 5 2
5 RAL+ETR+3TC/AZT 20.35 1.67 6 2
5 RAL+ETR+AZT+FTC 20.55 1.67 7 2
5 LEN+RAL+IBA+ETR 21.1 3.33 4 2
5 LEN+RAL+FTR+ETR 21.85 3.33 6 2
5 LEN+RAL+MVC+ETR 23.25 3.33 6 2

Report

Preferred regimen based on the HIV-ASSIST algorithm: DTG+DRV/c

DTG+DRV/c had the lowest weighted score (1.75) among all regimens HIV-ASSIST evaluated. In general, lower HIV-ASSIST weighted scores are considered preferable with respect to achieving viral suppression and maximizing tolerability. Your patient may have other considerations we did not factor and this report should not be considered a guarantee of likely success with this patient. Please use clinical judgement in making final ARV selections. Other regimens you may wish to consider are listed below. A full list of ARV regimens analyzed by the HIV-ASSIST algorithm can be found by clicking the Expert Tab above.

Score Code Regimen Weighted Score Active Drugs Total Pills Frequency (x/day)
2 DTG+DRV/c 1.75 2 2 1

The rationale behind why this regimen was chosen by our algorithm as the most appropriate is shown below:

Other highly ranked regimens

Other highly ranked regimens based on the HIV-ASSIST algorithm are shown below. For full details on these regimens, please click on the Expert Tab above.

Score Code Regimen Weighted Score Active Drugs Total Pills Frequency (x/day)
2 DTG+DRV/c/TAF/FTC 1.9 2.67 2 1
2 DRV/c+DTG/TDF/3TC 2 2.67 2 1
2 DRV/c+BIC/TAF/FTC 2 2.67 2 1
2 DTG+DRV/c+DOR 2.06 3 3 1

Mutations

Based on the Stanford Database, we assign penalties to various regimens based on inputted (i.e., genotypic) and assumed archived mutations. We consider drugs with summed mutation scores between 10 and 29 to have low-level resistance, scores between 30 and 59 to have intermediate-level resistance, and scores above 60 to have high-level resistance.

* signifies an assumed archived mutation based on prior treatment experience.
NRTI Mutation(s) 3TC FTC ABC TAF TDF AZT D4T DDI
L74V 0 0 30 0 0 0 0 60
Y115F 0 0 30 15 15 0 0 0
M184V 60 60 15 -10 -10 -10 -10 10
T215Y 0 0 10 10 10 60 40 15
L74V + M184IV 0 0 15 0 0 0 0 0
Total 60 60 100 15 15 50 30 85
NNRTI Mutation(s) EFV ETR RPV NVP DOR
K101H 10 10 10 15 0
Y181C 30 30 45 60 10
K101E + Y181C 5 5 0 5 0
Total 45 45 55 80 10
PI Mutation(s) LPVr FPVr TPVr SQVr IDVr NFV ATVr ATVc ATV DRV DRVr DRVc
Total 0 0 0 0 0 0 0 0 0 0 0 0
INSTI Mutation(s) RAL EVGc DTG BIC CAB
Total 0 0 0 0 0
EI Mutation(s) MVC IBA FOS
Total 0 0 0
CI Mutation(s) LEN
Total 0

Comorbidities, Side Effects, and Pregnancy Interactions

HIV-ASSIST incorporates a mathematical penalty into our algorithms for ARVs that are less preferred due to comorbidities or side-effects, based on recommendations from DHHS guidelines and HIV-ASSIST clinician and pharmacist expertise. In general, higher penalties suggest that the listed ARV is less favored in the presence of the stated comorbidity or side effect.

Co-medication Interactions

We have identified the following possible drug interactions which HIV-ASSIST factors into ARV regimen selection, based on recommendations from DHHS guidelines, University of Liverpool HIV Drug Interaction Checker, and HIV-ASSIST clinician and pharmacist expertise. Penalties less than 1.0 are typically those representing minor interactions that can be mediated by dosage adjustments, whereas a penalty of 2.0 represents medically contraindicated ARVs.